Diagnosis of latent autoimmune diabetes in adults (LADA) is usually based on the adult age, islet antibody detection, and insulin independence. This study investigates the diagnostic value of antibodies against glutamic acid decarboxylase (GAD) peptides in LADA and type 1 diabetes mellitus (T1DM) patients, and their cross-reactivity with an Enterovirus-Coxsackie-B4 (CVB4) shared epitope.
Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human Glutamic Acid Decarboxylase detecting antibodies in Latent Autoimmune Diabetes in Adults versus Type 1 Diabetes / Real-Fernández, Feliciana; Gallo, Alessandra; Nuti, Francesca; Altamore, Lorenzo; Giovanna Del Vescovo, Gloria; Traldi, Pietro; Ragazzi, Eugenio; Rovero, Paolo; Lapolla, Annunziata; Maria Papini, Anna. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - ELETTRONICO. - 515:(2021), pp. 73-79. [10.1016/j.cca.2021.01.002]
Cross-reactive peptide epitopes of Enterovirus Coxsackie B4 and human Glutamic Acid Decarboxylase detecting antibodies in Latent Autoimmune Diabetes in Adults versus Type 1 Diabetes
Real-Fernández, Feliciana;Nuti, Francesca;Altamore, Lorenzo;Giovanna Del Vescovo, Gloria;Rovero, Paolo;Maria Papini, Anna
2021
Abstract
Diagnosis of latent autoimmune diabetes in adults (LADA) is usually based on the adult age, islet antibody detection, and insulin independence. This study investigates the diagnostic value of antibodies against glutamic acid decarboxylase (GAD) peptides in LADA and type 1 diabetes mellitus (T1DM) patients, and their cross-reactivity with an Enterovirus-Coxsackie-B4 (CVB4) shared epitope.
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