Cardiovascular disease (CVD) is prevalent in women after menopause, which may be associated with obesity, insulin resistance and metaflammation. Despite the recognized role of immunological mechanisms in vascular remodeling, the role of dendritic cells (DCs) is still unclear. The aim was to characterize monocyte-derived DCs (Mo-DC) in post-menopausal patients with type 2 diabetes (T2DM) and obese woman, without clinical manifestations of atherosclerosis.
Insulin resistance and obesity affect monocyte-derived dendritic cell phenotype and function / Paccosi, Sara; Pala, Laura; Cresci, Barbara; Silvano, Angela; Cecchi, Marta; Caporale, Roberto; Maria Rotella, Carlo; Parenti, Astrid. - In: DIABETES RESEARCH AND CLINICAL PRACTICE. - ISSN 0168-8227. - ELETTRONICO. - 170:(2020), pp. 108528-108536. [10.1016/j.diabres.2020.108528]
Insulin resistance and obesity affect monocyte-derived dendritic cell phenotype and function
Paccosi, SaraInvestigation
;Pala, LauraConceptualization
;Cresci, BarbaraConceptualization
;Silvano, AngelaInvestigation
;Cecchi, MartaMethodology
;Caporale, RobertoMethodology
;Maria Rotella, CarloSupervision
;Parenti, Astrid
Project Administration
2020
Abstract
Cardiovascular disease (CVD) is prevalent in women after menopause, which may be associated with obesity, insulin resistance and metaflammation. Despite the recognized role of immunological mechanisms in vascular remodeling, the role of dendritic cells (DCs) is still unclear. The aim was to characterize monocyte-derived DCs (Mo-DC) in post-menopausal patients with type 2 diabetes (T2DM) and obese woman, without clinical manifestations of atherosclerosis.File | Dimensione | Formato | |
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DIAB-2020.pdf
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