The study uncovers the link between the central effector of DNA damage response, CHK2, and cellular metabolism. Furthermore, this study provides evidence that CHK2 mRNA contained in the extracellular vesicles isolated from blood is a reliable biomarker of human hepatocellular carcinoma
DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer / Matteo Lulli, Laura Del Coco, Tommaso Mello, Caecilia Sukowati, Stefania Madiai, Laura Gragnani, Paolo Forte , Francesco Paolo Fanizzi, Antonio Mazzocca, Krista Rombouts , Andrea Galli, Vinicio Carloni. - In: CANCER RESEARCH. - ISSN 0008-5472. - STAMPA. - 81:(2021), pp. 2861-2873. [10.1158/0008-5472.CAN-20-3134]
DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer
Matteo Lulli;Tommaso Mello;Stefania Madiai;Laura Gragnani;Francesco Paolo Fanizzi;Antonio Mazzocca;Krista Rombouts;Andrea Galli;Vinicio Carloni
Conceptualization
2021
Abstract
The study uncovers the link between the central effector of DNA damage response, CHK2, and cellular metabolism. Furthermore, this study provides evidence that CHK2 mRNA contained in the extracellular vesicles isolated from blood is a reliable biomarker of human hepatocellular carcinoma
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CANCER_RESEARCH2021.pdf
accesso aperto
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