Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity

Milito, C.; Lougaris, V.; Giardino, G.; Punziano, A.; Vultaggio, A.; Carrabba, M.; Cinetto, F.; Scarpa, R.; Delle Piane, R. M.; Baselli, L.; Ricci, S.; Rivalta, B.; Conti, F.; Marasco, C.; Marzollo, A.; Firinu, D.; Pulvirenti, F.; Lagnese, G.; Vivarelli, E.; Cancrini, C.; Martire, B.; Danieli, M. G.; Pession, A.; Vacca, A.; Azzari, C.; Fabio, G.; Matucci, A.; Soresina, A. R.; Agostini, C.; Spadaro, G.; Badolato, R.; Cicalese, M. P.; Aiuti, A.; Plebani, A.; Pignata, C.; Quinti, I.

doi:10.1016/j.jaip.2021.04.017

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients with inborn errors of immunity (IEI) showed a similar infection-fatality rate, a lower incidence in pediatric age, and a younger age at death than the SARS-CoV-2–positive Italian population. The fatality rate was lower than previously reported from other IEI cohorts. Antibody deficiencies showed a long-lasting SARS-CoV-2 positivity.

Clinical outcome, incidence, and SARS-CoV-2 infection-fatality rates in Italian patients with inborn errors of immunity / Milito C., Lougaris V., Giardino G., Punziano A., Vultaggio A., Carrabba M., Cinetto F., Scarpa R., Delle Piane R.M., Baselli L., Ricci S., Rivalta B., Conti F., Marasco C., Marzollo A., Firinu D., Pulvirenti F., Lagnese G., Vivarelli E., Cancrini C., et al.. - In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE. - ISSN 2213-2198. - ELETTRONICO. - 9:(2021), pp. 2904-2906.e2. [10.1016/j.jaip.2021.04.017]