In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.
Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development / Lionetti V.; Bollini S.; Coppini R.; Gerbino A.; Ghigo A.; Iaccarino G.; Madonna R.; Mangiacapra F.; Miragoli M.; Moccia F.; Munaron L.; Pagliaro P.; Parenti A.; Pasqua T.; Penna C.; Quaini F.; Rocca C.; Samaja M.; Sartiani L.; Soda T.; Tocchetti C.G.; Angelone T.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - ELETTRONICO. - 168:(2021), pp. 105581-105593. [10.1016/j.phrs.2021.105581]
Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development
Coppini R.Membro del Collaboration Group
;Munaron L.;Parenti A.Membro del Collaboration Group
;Rocca C.;Sartiani L.Membro del Collaboration Group
;
2021
Abstract
In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.
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