Hypoxia and HIFs (hypoxia inducible factors) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation significantly contributed to NAFLD progression in experimental animals and human patients. In this study we investigated mechanistically, using an appropriate genetic murine model, the involvement of hepatocyte HIF-2α in experimental NASH-related carcinogenesis.

Hepatocyte-specific deletion of HIF2α prevents NASH-related liver carcinogenesis by decreasing cancer cell proliferation / Foglia, Beatrice; Sutti, Salvatore; Cannito, Stefania; Rosso, Chiara; Maggiora, Marina; Autelli, Riccardo; Novo, Erica; Bocca, Claudia; Villano, Gianmarco; Ramavath, Naresh Naik; Younes, Ramy; Tusa, Ignazia; Rovida, Elisabetta; Pontisso, Patrizia; Bugianesi, Elisabetta; Albano, Emanuele; Parola, Maurizio. - In: CMGH. - ISSN 2352-345X. - STAMPA. - 13:(2022), pp. 459-482. [10.1016/j.jcmgh.2021.10.002]

Hepatocyte-specific deletion of HIF2α prevents NASH-related liver carcinogenesis by decreasing cancer cell proliferation

Tusa, Ignazia;Rovida, Elisabetta;
2022

Abstract

Hypoxia and HIFs (hypoxia inducible factors) are involved in chronic liver disease progression. We previously showed that hepatocyte HIF-2α activation significantly contributed to NAFLD progression in experimental animals and human patients. In this study we investigated mechanistically, using an appropriate genetic murine model, the involvement of hepatocyte HIF-2α in experimental NASH-related carcinogenesis.
2022
13
459
482
Goal 3: Good health and well-being for people
Foglia, Beatrice; Sutti, Salvatore; Cannito, Stefania; Rosso, Chiara; Maggiora, Marina; Autelli, Riccardo; Novo, Erica; Bocca, Claudia; Villano, Gianm...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1245689
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