Background: To report a clinical case of a patient affected with choroideremia (CHM) who underwent macular surgery for a macular hole (MH) with Lamellar Hole-associated Epiretinal Proliferation (LHEP). Case presentation: We have described a 48-year-old male patient affected with CHM who developed MH with LHEP over a 7-year follow-up. The patient was referred to the Regional Center for Hereditary Retinal Degenerations of the Eye Clinic in Florence (Italy) in April 2012. The patient underwent vitrectomy and Inner Limiting Membrane (ILM) and LHEP peeling with fluid-air exchange. Ultra-structural examination of the excised epiretinal proliferation, carried out using electron microscopy, showed dense amorphous material, mainly composed of abundant clusters of fibrous collagens resembling compact fibrous long spacing collagen (FLSC), embedded in native vitreous collagen (NVC) and type IV collagen. No cells were detected in any of the specimens collected. At the 3rd-week postoperative followup the macular hole was closed. Conclusion: Macular hole with LHEP can be detected in CHM patients; in our patient the macular hole showed tractional and degenerative features, with good anatomical results after macular surgery. Keywords: CHM, LHEP, Macular hole, Vitrectomy, Peeling, Electron microscopy, OCT, Lamellar Hole-associated Epiretinal Proliferation

Lamellar Hole-associated Epiretinal Proliferation in choroideremia: a case report / Murro, Vittoria; Mucciolo, Dario Pasquale; Giorgio, Dario; Caporossi, Tomaso; Passerini, Ilaria; Bani, Daniele; Giansanti, Fabrizio; Virgili, Gianni; Sodi, Andrea. - In: INTERNATIONAL JOURNAL OF RETINA AND VITREOUS. - ISSN 2056-9920. - ELETTRONICO. - 7:(2021), pp. 1-5. [10.1186/s40942-021-00333-5]

Lamellar Hole-associated Epiretinal Proliferation in choroideremia: a case report

Murro, Vittoria;Mucciolo, Dario Pasquale;Giorgio, Dario;Caporossi, Tomaso;Passerini, Ilaria;Bani, Daniele;Giansanti, Fabrizio;Virgili, Gianni;Sodi, Andrea
2021

Abstract

Background: To report a clinical case of a patient affected with choroideremia (CHM) who underwent macular surgery for a macular hole (MH) with Lamellar Hole-associated Epiretinal Proliferation (LHEP). Case presentation: We have described a 48-year-old male patient affected with CHM who developed MH with LHEP over a 7-year follow-up. The patient was referred to the Regional Center for Hereditary Retinal Degenerations of the Eye Clinic in Florence (Italy) in April 2012. The patient underwent vitrectomy and Inner Limiting Membrane (ILM) and LHEP peeling with fluid-air exchange. Ultra-structural examination of the excised epiretinal proliferation, carried out using electron microscopy, showed dense amorphous material, mainly composed of abundant clusters of fibrous collagens resembling compact fibrous long spacing collagen (FLSC), embedded in native vitreous collagen (NVC) and type IV collagen. No cells were detected in any of the specimens collected. At the 3rd-week postoperative followup the macular hole was closed. Conclusion: Macular hole with LHEP can be detected in CHM patients; in our patient the macular hole showed tractional and degenerative features, with good anatomical results after macular surgery. Keywords: CHM, LHEP, Macular hole, Vitrectomy, Peeling, Electron microscopy, OCT, Lamellar Hole-associated Epiretinal Proliferation
2021
7
1
5
Murro, Vittoria; Mucciolo, Dario Pasquale; Giorgio, Dario; Caporossi, Tomaso; Passerini, Ilaria; Bani, Daniele; Giansanti, Fabrizio; Virgili, Gianni; Sodi, Andrea
File in questo prodotto:
File Dimensione Formato  
40942_2021_Article_333.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: Tutti i diritti riservati
Dimensione 1.28 MB
Formato Adobe PDF
1.28 MB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1245983
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 1
social impact