Direct reprogrammin of reactive astrocytes into neurons in mouse motor cortex after stroke

In this thesis, I tested the effect of using “reprogramming” transcription factors to directly convert reactive astrocytes into new neurons after a focal cortical ischemic injury in the primary motor cortex. Direct reprogramming of endogenous astrocytes in the mouse motor cortex is capable to produce a new neuronal population that acquire a motor identity, integrate in the host tissue and support the recovery of function of the affected forelimb.