Studying peptide amphiphiles (PAs), we investigate the influence of alkyl chain length on the aggregation behavior of the collagen-derived peptide KTTKS with applications ranging from antiwrinkle cosmetic creams to potential uses in regenerative medicine. We have studied synthetic peptides amphiphiles C 14-KTTKS (myristoyl-Lys-Thr-Thr-Lys-Ser) and C18-KTTKS (stearoyl-Lys-Thr-Thr-Lys-Ser) to investigate in detail their physicochemical properties. It is presumed that the hydrophobic chain in these self-assembling peptide amphiphiles enhances peptide permeation across the skin compared to KTTKS alone. Subsequently Cn-KTTKS should act as a prodrug and release the peptide by enzymatic cleavage. Our results should be useful in the further development of molecules with collagen-stimulating activity. © 2012 American Chemical Society.

Conformation and self-association of peptide amphiphiles based on the KTTKS collagen sequence / Palladino P.; Castelletto V.; Dehsorkhi A.; Stetsenko D.; Hamley I.W.. - In: LANGMUIR. - ISSN 0743-7463. - ELETTRONICO. - 28:(2012), pp. 12209-12215. [10.1021/la302123h]

Conformation and self-association of peptide amphiphiles based on the KTTKS collagen sequence

Palladino P.;
2012

Abstract

Studying peptide amphiphiles (PAs), we investigate the influence of alkyl chain length on the aggregation behavior of the collagen-derived peptide KTTKS with applications ranging from antiwrinkle cosmetic creams to potential uses in regenerative medicine. We have studied synthetic peptides amphiphiles C 14-KTTKS (myristoyl-Lys-Thr-Thr-Lys-Ser) and C18-KTTKS (stearoyl-Lys-Thr-Thr-Lys-Ser) to investigate in detail their physicochemical properties. It is presumed that the hydrophobic chain in these self-assembling peptide amphiphiles enhances peptide permeation across the skin compared to KTTKS alone. Subsequently Cn-KTTKS should act as a prodrug and release the peptide by enzymatic cleavage. Our results should be useful in the further development of molecules with collagen-stimulating activity. © 2012 American Chemical Society.
28
12209
12215
Palladino P.; Castelletto V.; Dehsorkhi A.; Stetsenko D.; Hamley I.W.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1256435
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