We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4{29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4{29-39}.
A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor 4 / Palladino P.; Pedone C.; Ragone R.; Rossi F.; Saviano M.; Benedetti E.. - In: PROTEIN AND PEPTIDE LETTERS. - ISSN 0929-8665. - ELETTRONICO. - 10:(2003), pp. 133-138. [10.2174/0929866033479022]
A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor 4
Palladino P.;
2003
Abstract
We have synthesised the CXC chemokine receptor 4 (29-39) peptide, CXCR4{29-39}. This peptide is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Preliminary experiments, performed in the presence of micellar detergents to model a membrane-like environment, show that the (1-17) segment of SDF-1 binds to CXCR4{29-39}.
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