In conclusion, the detection of the BCL-2 molecule by immunohistochemistry in PC-FLC should not surprise clinicians. Furthermore, t (14, 18) translocation can be observed especially at FISH analysis, which can be more reliable and accurate in detecting gene abnormalities than PCR. Due to the absence of long-term follow up studies, clinicians should accurately stage and follow up patients, albeit there is no clear-cut evidence supporting a worse prognostic significance. Essentially, the accurate stage and follow up is meant to avoid the risk to misdiagnose a systemic form as a PC one. More and possibly perspective studies should be warranted to better define the clinical and biological landscape of PC-FCL.

BCL-2 Expression in Primary Cutaneous Follicle Center B-Cell Lymphoma and Its Prognostic Role / Pileri A.; Agostinelli C.; Bertuzzi C.; Grandi V.; Maio V.; Lastrucci I.; Santucci M.; Pimpinelli N.. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - ELETTRONICO. - 10:(2020), pp. 0-0. [10.3389/fonc.2020.00662]

BCL-2 Expression in Primary Cutaneous Follicle Center B-Cell Lymphoma and Its Prognostic Role

Pileri A.
;
Grandi V.
Membro del Collaboration Group
;
Maio V.
Membro del Collaboration Group
;
Lastrucci I.
Membro del Collaboration Group
;
Santucci M.
Membro del Collaboration Group
;
Pimpinelli N.
2020

Abstract

In conclusion, the detection of the BCL-2 molecule by immunohistochemistry in PC-FLC should not surprise clinicians. Furthermore, t (14, 18) translocation can be observed especially at FISH analysis, which can be more reliable and accurate in detecting gene abnormalities than PCR. Due to the absence of long-term follow up studies, clinicians should accurately stage and follow up patients, albeit there is no clear-cut evidence supporting a worse prognostic significance. Essentially, the accurate stage and follow up is meant to avoid the risk to misdiagnose a systemic form as a PC one. More and possibly perspective studies should be warranted to better define the clinical and biological landscape of PC-FCL.
2020
10
0
0
Pileri A.; Agostinelli C.; Bertuzzi C.; Grandi V.; Maio V.; Lastrucci I.; Santucci M.; Pimpinelli N.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1256593
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