Background: Italy is considered an area with very low HAV (hepatitis A virus) endemicity. Currently in Italy the anti-HAV vaccine is recommended only for specific risk groups and there is no universal vaccination program. The aim of this study was to assess the level of immunity against hepatitis A in a sample of children and adolescents from the province of Florence. Methods: A total of 165 sera were collected from subjects aged 1 to 18 years, proportionally selected according to the general population size and stratified by age and sex. A qualitative evaluation of anti-HAV antibodies was performed using the enzyme-linked immunosorbent assay (ELISA). Anamnestic and vaccination status data were also collected. Results: Our study showed a hepatitis A seroprevalence of 9.1% in the enrolled population. A statistically significant difference in the prevalence of anti-HAV was found between Italian and non-Italian subjects. About half of the population having anti-HAV antibodies was reported to be vaccinated, and no cases of hepatitis A were found. Conclusions: The data from our study confirmed Tuscany as an area with low HAV endemicity and showed that hepatitis A seroprevalence is significantly higher in foreign children and adolescents. The presence of more seropositive subjects than those vaccinated was probably due to a natural immunization achieved through a subclinical infection and/or to underreporting of the surveillance systems.

A study of hepatitis a seroprevalence in a paediatric and adolescent population of the province of florence (Italy) in the period 2017–2018 confirms tuscany a low endemic area / Zanella B.; Boccalini S.; Biamonte M.A.; Giorgetti D.; Menicacci M.; Bonito B.; Ninci A.; Tiscione E.; Puggelli F.; Mereu G.; Working Group DHS; Working Group AOUMeyer; Working Group AUSLTC; Bonanni P.; Bechini A.. - In: VACCINES. - ISSN 2076-393X. - ELETTRONICO. - 9:(2021), pp. 1194-1205. [10.3390/VACCINES9101194]

A study of hepatitis a seroprevalence in a paediatric and adolescent population of the province of florence (Italy) in the period 2017–2018 confirms tuscany a low endemic area

Zanella B.;Boccalini S.;Biamonte M. A.;Giorgetti D.;Menicacci M.;Bonito B.;Ninci A.;Tiscione E.;Mereu G.;Bonanni P.;Bechini A.
2021

Abstract

Background: Italy is considered an area with very low HAV (hepatitis A virus) endemicity. Currently in Italy the anti-HAV vaccine is recommended only for specific risk groups and there is no universal vaccination program. The aim of this study was to assess the level of immunity against hepatitis A in a sample of children and adolescents from the province of Florence. Methods: A total of 165 sera were collected from subjects aged 1 to 18 years, proportionally selected according to the general population size and stratified by age and sex. A qualitative evaluation of anti-HAV antibodies was performed using the enzyme-linked immunosorbent assay (ELISA). Anamnestic and vaccination status data were also collected. Results: Our study showed a hepatitis A seroprevalence of 9.1% in the enrolled population. A statistically significant difference in the prevalence of anti-HAV was found between Italian and non-Italian subjects. About half of the population having anti-HAV antibodies was reported to be vaccinated, and no cases of hepatitis A were found. Conclusions: The data from our study confirmed Tuscany as an area with low HAV endemicity and showed that hepatitis A seroprevalence is significantly higher in foreign children and adolescents. The presence of more seropositive subjects than those vaccinated was probably due to a natural immunization achieved through a subclinical infection and/or to underreporting of the surveillance systems.
2021
9
1194
1205
Zanella B.; Boccalini S.; Biamonte M.A.; Giorgetti D.; Menicacci M.; Bonito B.; Ninci A.; Tiscione E.; Puggelli F.; Mereu G.; Working Group DHS; Working Group AOUMeyer; Working Group AUSLTC; Bonanni P.; Bechini A.
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1257668
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