The role of oxidative stress and the TRPA1 and TRPV4 channels in cancer-related pain syndromes

The main purpose of this three-year study was to investigate in different pain models the ability of oxidative stress byproducts to target TRPA1 and TRPV4 on neighboring nociceptors, to initiate and maintain spontaneous pain and hypersensitivity conditions, in different models of pain, either inflammatory or neuropathic. The development of novel therapeutic strategies, involving the administration of specific antagonists that target these channels could improve pain conditions such as neuropathic, migraine, cancer related pain as well as the neuropathy derived from the treatment with anticancer drugs, thus ameliorating the patients’ quality of life.