We aimed to assess the effect of the Intermediate Allele of huntingtin gene on progression of cognitive impairment in patients with subjective cognitive decline (SCD). Intermediate alleles interact with age and APOE ɛ4, increasing the risk of progression to MCI in SCD patients.
Huntingtin gene intermediate alleles influence the progression from subjective cognitive decline to mild cognitive impairment: A 14-year follow-up study / Salvatore Mazzeo; Filippo Emiliani; Silvia Bagnoli; Sonia Padiglioni; Vittoria Conti; Assunta Ingannato; Giulia Giacomucci; Juri Balestrini; Camilla Ferrari; Sandro Sorbi; Benedetta Nacmias; Valentina Bessi. - In: EUROPEAN JOURNAL OF NEUROLOGY. - ISSN 1351-5101. - ELETTRONICO. - 29:(2022), pp. 1600-1609. [10.1111/ene.15291]
Huntingtin gene intermediate alleles influence the progression from subjective cognitive decline to mild cognitive impairment: A 14-year follow-up study
Salvatore Mazzeo;Filippo Emiliani;Silvia Bagnoli;Sonia Padiglioni;Vittoria Conti;Assunta Ingannato;Giulia Giacomucci;Juri Balestrini;Camilla Ferrari;Sandro Sorbi;Benedetta Nacmias;Valentina Bessi
2022
Abstract
We aimed to assess the effect of the Intermediate Allele of huntingtin gene on progression of cognitive impairment in patients with subjective cognitive decline (SCD). Intermediate alleles interact with age and APOE ɛ4, increasing the risk of progression to MCI in SCD patients.
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