HTT is a gene containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. HTT genes with <35 repeats are not associated with HD. The biological function of CAG repeat expansion below the non-pathological threshold is not well understood. In fact higher number of repeats in HTT confer advantageous changes in brain structure and general intelligence, but several studies focused on establishing the association between CAG expansions and susceptibility to psychiatric disturbances and to other neurodegenerative disease than HD. We hypothesized that HTT CAG repeat length below the pathological threshold might influence mood and personality traits in a longitudinal sample of individuals with Subjective Cognitive Decline.

CAG Repeats Within the Non-pathological Range in the HTT Gene Influence Personality Traits in Patients With Subjective Cognitive Decline: A 13-Year Follow-Up Study / Moschini, Valentina; Mazzeo, Salvatore; Bagnoli, Silvia; Padiglioni, Sonia; Emiliani, Filippo; Giacomucci, Giulia; Morinelli, Carmen; Ingannato, Assunta; Freni, Tommaso; Belloni, Laura; Ferrari, Camilla; Sorbi, Sandro; Nacmias, Benedetta; Bessi, Valentina. - In: FRONTIERS IN PSYCHIATRY. - ISSN 1664-0640. - ELETTRONICO. - 13:(2022), pp. 826135-826144. [10.3389/fpsyt.2022.826135]

CAG Repeats Within the Non-pathological Range in the HTT Gene Influence Personality Traits in Patients With Subjective Cognitive Decline: A 13-Year Follow-Up Study

Moschini, Valentina;Mazzeo, Salvatore;Bagnoli, Silvia;Padiglioni, Sonia;Emiliani, Filippo;Giacomucci, Giulia;Ingannato, Assunta;Belloni, Laura;Ferrari, Camilla;Sorbi, Sandro;Nacmias, Benedetta;Bessi, Valentina
2022

Abstract

HTT is a gene containing a key region of CAG repeats. When expanded beyond 39 repeats, Huntington disease (HD) develops. HTT genes with <35 repeats are not associated with HD. The biological function of CAG repeat expansion below the non-pathological threshold is not well understood. In fact higher number of repeats in HTT confer advantageous changes in brain structure and general intelligence, but several studies focused on establishing the association between CAG expansions and susceptibility to psychiatric disturbances and to other neurodegenerative disease than HD. We hypothesized that HTT CAG repeat length below the pathological threshold might influence mood and personality traits in a longitudinal sample of individuals with Subjective Cognitive Decline.
13
826135
826144
Moschini, Valentina; Mazzeo, Salvatore; Bagnoli, Silvia; Padiglioni, Sonia; Emiliani, Filippo; Giacomucci, Giulia; Morinelli, Carmen; Ingannato, Assunta; Freni, Tommaso; Belloni, Laura; Ferrari, Camilla; Sorbi, Sandro; Nacmias, Benedetta; Bessi, Valentina
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1277741
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