We aimed to identify features associated with different disease trajectories in Alzheimer's disease (AD)-related primary progressive aphasia (PPA). We considered 23 patients diagnosed with AD-related PPA. All patients underwent neuropsychological evaluation, 18F-Fluorodeoxyglucose-PET brain scan, CSF biomarkers measurement and APOE genotype analysis at baseline and underwent neurological follow-up for a mean time of 3 years. Patients who progressed to total loss of speech (TLoS+) had greater impairment in writing and higher t-tau concentration as compared to TLoS- patients. Patients who progressed to loss of functional autonomy (LoFA+) had greater impairment in single-word comprehension as compared to patients who maintained autonomy in self-care. Furthermore, 18F-FDG-PET SPM analyses revealed different brain metabolic patterns between TLoS+ and TLoS- and between LoFA+ and LoFA-. In conclusion, linguistic profile, CSF t-tau and brain metabolic pattern might be useful tools to predict progression to total loss of speech and loss of functional autonomy in AD-related PPA patients.

Loss of speech and functional impairment in Alzheimer's disease-related primary progressive aphasia: predictive factors of decline / Salvatore Mazzeo , Cristina Polito , Michael Lassi , Silvia Bagnoli , Marta Mattei , Sonia Padiglioni , Valentina Berti , Gemma Lombardi , Giulia Giacomucci , Maria Teresa De Cristofaro , Alessandro Passeri , Camilla Ferrari , Benedetta Nacmias , Alberto Mazzoni , Sandro Sorbi , Valentina Bessi. - In: NEUROBIOLOGY OF AGING. - ISSN 1558-1497. - ELETTRONICO. - 117:(2022), pp. 59-70. [10.1016/j.neurobiolaging.2022.05.002]

Loss of speech and functional impairment in Alzheimer's disease-related primary progressive aphasia: predictive factors of decline

Salvatore Mazzeo;Cristina Polito;Silvia Bagnoli;Marta Mattei;Sonia Padiglioni;Valentina Berti;Gemma Lombardi;Giulia Giacomucci;Maria Teresa De Cristofaro;Alessandro Passeri;Camilla Ferrari;Benedetta Nacmias;Sandro Sorbi;Valentina Bessi
2022

Abstract

We aimed to identify features associated with different disease trajectories in Alzheimer's disease (AD)-related primary progressive aphasia (PPA). We considered 23 patients diagnosed with AD-related PPA. All patients underwent neuropsychological evaluation, 18F-Fluorodeoxyglucose-PET brain scan, CSF biomarkers measurement and APOE genotype analysis at baseline and underwent neurological follow-up for a mean time of 3 years. Patients who progressed to total loss of speech (TLoS+) had greater impairment in writing and higher t-tau concentration as compared to TLoS- patients. Patients who progressed to loss of functional autonomy (LoFA+) had greater impairment in single-word comprehension as compared to patients who maintained autonomy in self-care. Furthermore, 18F-FDG-PET SPM analyses revealed different brain metabolic patterns between TLoS+ and TLoS- and between LoFA+ and LoFA-. In conclusion, linguistic profile, CSF t-tau and brain metabolic pattern might be useful tools to predict progression to total loss of speech and loss of functional autonomy in AD-related PPA patients.
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Salvatore Mazzeo , Cristina Polito , Michael Lassi , Silvia Bagnoli , Marta Mattei , Sonia Padiglioni , Valentina Berti , Gemma Lombardi , Giulia Giacomucci , Maria Teresa De Cristofaro , Alessandro Passeri , Camilla Ferrari , Benedetta Nacmias , Alberto Mazzoni , Sandro Sorbi , Valentina Bessi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2158/1280629
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