In rodent motor cortex, the rostral forelimb area (RFA) and the caudal forelimb area (CFA) are major actors in orchestrating the control of forelimb complex movements. However, their intrinsic connections and reciprocal functional organization are still unclear, limiting our understanding of how the brain coordinates and executes voluntary movements. Here we causally probed cortical connectivity and activation patterns triggered by transcranial optogenetic stimulation of ethologically relevant complex movements exploiting a novel large-scale all-optical method in awake mice. Results show specific activation features for each movement class, providing evidence for a segregated functional organization of CFA and RFA. Importantly, we identified a second discrete lateral grasping representation area, namely lateral forelimb area (LFA), with unique connectivity and activation patterns. Therefore, we propose the LFA as a distinct motor representation in the forelimb somatotopic motor map.

Large-scale all-optical dissection of motor cortex connectivity reveals a segregated functional organization of mouse forelimb representations / Francesco Resta, Elena Montagni, Giuseppe de Vito, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone. - In: CELL REPORTS. - ISSN 2211-1247. - ELETTRONICO. - -:(In corso di stampa), pp. 0-0.

Large-scale all-optical dissection of motor cortex connectivity reveals a segregated functional organization of mouse forelimb representations

Francesco Resta
;
Elena Montagni;Giuseppe de Vito;Alessandro Scaglione;Anna Letizia Allegra Mascaro
;
Francesco Saverio Pavone
In corso di stampa

Abstract

In rodent motor cortex, the rostral forelimb area (RFA) and the caudal forelimb area (CFA) are major actors in orchestrating the control of forelimb complex movements. However, their intrinsic connections and reciprocal functional organization are still unclear, limiting our understanding of how the brain coordinates and executes voluntary movements. Here we causally probed cortical connectivity and activation patterns triggered by transcranial optogenetic stimulation of ethologically relevant complex movements exploiting a novel large-scale all-optical method in awake mice. Results show specific activation features for each movement class, providing evidence for a segregated functional organization of CFA and RFA. Importantly, we identified a second discrete lateral grasping representation area, namely lateral forelimb area (LFA), with unique connectivity and activation patterns. Therefore, we propose the LFA as a distinct motor representation in the forelimb somatotopic motor map.
-
0
0
Francesco Resta, Elena Montagni, Giuseppe de Vito, Alessandro Scaglione, Anna Letizia Allegra Mascaro, Francesco Saverio Pavone
File in questo prodotto:
File Dimensione Formato  
2021.07.15.452461v1.full.pdf

accesso aperto

Descrizione: Preprint
Tipologia: Preprint (Submitted version)
Licenza: Creative commons
Dimensione 2.37 MB
Formato Adobe PDF
2.37 MB Adobe PDF Visualizza/Apri

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1285392
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact