The putative tumour suppressor gene FHIT (fragile histidine triad) spans the common fragile site FRA3B, which is highly susceptible to breaks and deletions induced by genotoxic agents. Tumours associated with exposure to carcinogens, such as colorectal adenocarcinomas, should be particularly susceptible to alterations in the FHIT gene. We studied the frequency of FHIT alterations and their correlations with clinicopathologic features in sporadic colon carcinomas.

Clinicopathologic features and FHIT gene expression in sporadic colorectal adenocarcinomas / Luceri, C; Guglielmi, F; De Filippo, C; Caderni, G; Mini, E; Biggeri, A; Napoli, C; Tonelli, F; Cianchi, F; Dolara, P. - In: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0036-5521. - STAMPA. - 35:(2000), pp. 637-641. [10.1080/003655200750023615]

Clinicopathologic features and FHIT gene expression in sporadic colorectal adenocarcinomas

Luceri, C;Caderni, G;Mini, E;
2000

Abstract

The putative tumour suppressor gene FHIT (fragile histidine triad) spans the common fragile site FRA3B, which is highly susceptible to breaks and deletions induced by genotoxic agents. Tumours associated with exposure to carcinogens, such as colorectal adenocarcinomas, should be particularly susceptible to alterations in the FHIT gene. We studied the frequency of FHIT alterations and their correlations with clinicopathologic features in sporadic colon carcinomas.
2000
35
637
641
Luceri, C; Guglielmi, F; De Filippo, C; Caderni, G; Mini, E; Biggeri, A; Napoli, C; Tonelli, F; Cianchi, F; Dolara, P
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1285655
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