Primary progressive aphasia (PPA) classification relies on profile characterization of quantitatively impaired/spared performance in language tasks. In this study, we coextracted 8 qualitative types of errors in 67 PPA patients submitted to a comprehensive language assessment. Canonical correlation analysis was applied to simultaneously correlate qualitative errors and brain metabolism, collected with FDG-PET. Results showed the contribution of semantic, syntactic and working memory errors associated with specific correlates of regional metabolic changes. Reduced metabolism in the left fusiform gyrus, anterior-middle and inferior-temporal gyri and middle-temporal pole correlated with an increase of semantic errors. Hypometabolism in the left inferior, middle, and superior frontal gyri, insula and right middle-occipital gyrus was related to syntactic errors. Higher metabolism in the bilateral pallidum, putamen, and left thalamus, as well as hypometabolism in the left angular and supramarginal gyri, inferior-parietal lobule, posterior-middle and inferior-temporal gyri and posterior cingulum predicted the increase of working memory errors. A relevant role of working memory subcomponents was associated with distinct neural systems. Patients' profiles are easily represented in a qualitative multidimensional space, in which mixed PPA overlapped with different phenotypes.

Comprehensive qualitative characterization of linguistic performance profiles in primary progressive aphasia: a multivariate study with FDG-PET / Catricalà, Eleonora; Santi, Gaia C; Polito, Cristina; Conca, Francesca; Esposito, Valentina; Caminiti, Silvia P; Boccalini, Cecilia; Berti, Valentina; Bessi, Valentina; Marcone, Alessandra; Iannaccone, Sandro; Sorbi, Sandro; Perani, Daniela; Cappa, Stefano F. - In: NEUROBIOLOGY OF AGING. - ISSN 1558-1497. - ELETTRONICO. - 120:(2022), pp. 137-148. [10.1016/j.neurobiolaging.2022.09.001]

Comprehensive qualitative characterization of linguistic performance profiles in primary progressive aphasia: a multivariate study with FDG-PET

Polito, Cristina;Berti, Valentina;Bessi, Valentina;Sorbi, Sandro;
2022

Abstract

Primary progressive aphasia (PPA) classification relies on profile characterization of quantitatively impaired/spared performance in language tasks. In this study, we coextracted 8 qualitative types of errors in 67 PPA patients submitted to a comprehensive language assessment. Canonical correlation analysis was applied to simultaneously correlate qualitative errors and brain metabolism, collected with FDG-PET. Results showed the contribution of semantic, syntactic and working memory errors associated with specific correlates of regional metabolic changes. Reduced metabolism in the left fusiform gyrus, anterior-middle and inferior-temporal gyri and middle-temporal pole correlated with an increase of semantic errors. Hypometabolism in the left inferior, middle, and superior frontal gyri, insula and right middle-occipital gyrus was related to syntactic errors. Higher metabolism in the bilateral pallidum, putamen, and left thalamus, as well as hypometabolism in the left angular and supramarginal gyri, inferior-parietal lobule, posterior-middle and inferior-temporal gyri and posterior cingulum predicted the increase of working memory errors. A relevant role of working memory subcomponents was associated with distinct neural systems. Patients' profiles are easily represented in a qualitative multidimensional space, in which mixed PPA overlapped with different phenotypes.
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Catricalà, Eleonora; Santi, Gaia C; Polito, Cristina; Conca, Francesca; Esposito, Valentina; Caminiti, Silvia P; Boccalini, Cecilia; Berti, Valentina; Bessi, Valentina; Marcone, Alessandra; Iannaccone, Sandro; Sorbi, Sandro; Perani, Daniela; Cappa, Stefano F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/1285715
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