Radiation-induced cystitis is a common side effect of radiotherapy (RT) to the pelvic area. Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome. HA/CS may also have a protective effect against RT bladder toxicity.
Multicentre International Study for the Prevention with iAluRil of Radio-induced Cystitis (MISTIC): A Randomised Controlled Study / Redorta, Juan Palou; Sanguedolce, Francesco; Pardo, Gemma Sancho; Romancik, Martin; Vittori, Gianni; Minervini, Andrea; Di Maida, Fabrizio; Lunik, Richard; Colombo, Renzo; Serretta, Vincenzo; Çetinel, Bülent; Bini, Vittorio; Corradengo, Davide; Lazzeri, Massimo. - In: EUROPEAN UROLOGY OPEN SCIENCE. - ISSN 2666-1683. - ELETTRONICO. - 26:(2021), pp. 45-54. [10.1016/j.euros.2021.01.016]
Multicentre International Study for the Prevention with iAluRil of Radio-induced Cystitis (MISTIC): A Randomised Controlled Study
Vittori, Gianni;Minervini, Andrea;Di Maida, Fabrizio;
2021
Abstract
Radiation-induced cystitis is a common side effect of radiotherapy (RT) to the pelvic area. Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome. HA/CS may also have a protective effect against RT bladder toxicity.
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