Human carbonic anhydrases (CA, EC 4.2.1.1) IX and XII are tumor-associated proteins, being part of the molecular machinery that tumor cells build as adaptive responses to hypoxia and acidic conditions characteristic of the 'glycolytic shift' of many tumors. A wealth of research depicts CA IX and CA XII as biomarkers and therapeutic targets for various cancer types.
Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018) / Nocentini, Alessio; Supuran, Claudiu T. - In: EXPERT OPINION ON THERAPEUTIC PATENTS. - ISSN 1354-3776. - ELETTRONICO. - 28:(2018), pp. 729-740. [10.1080/13543776.2018.1508453]
Carbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018)
Nocentini, Alessio;Supuran, Claudiu T
2018
Abstract
Human carbonic anhydrases (CA, EC 4.2.1.1) IX and XII are tumor-associated proteins, being part of the molecular machinery that tumor cells build as adaptive responses to hypoxia and acidic conditions characteristic of the 'glycolytic shift' of many tumors. A wealth of research depicts CA IX and CA XII as biomarkers and therapeutic targets for various cancer types.
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