Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodeling in HCM.
RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy / Pisano, Annalinda; Pera, Loredana Le; Carletti, Raffaella; Cerbelli, Bruna; Pignataro, Maria G; Pernazza, Angelina; Ferre, Fabrizio; Lombardi, Maria; Lazzeroni, Davide; Olivotto, Iacopo; Rimoldi, Ornella E; Foglieni, Chiara; Camici, Paolo G; d'Amati, Giulia. - In: MICROCIRCULATION. - ISSN 1073-9688. - ELETTRONICO. - (2022), pp. 0-0. [10.1111/micc.12790]
RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy
Lombardi, Maria;Olivotto, Iacopo;
2022
Abstract
Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodeling in HCM.
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