The fragility index is a method to assess robustness of a clinical trial and is defined the minimum number of best survivors reassigned to the control group required to revert the statistically significant result of a clinical trial to non-significant. Among 25 randomized controlled trials in HCC, the median fragility index was 5 and ten trials among 25 (40%) had a fragility index of 2 or less indicating an important fragility.
Fragility index of positive phase II and III randomized clinical trials of treatments for hepatocellular carcinoma (2002-2022) / Sidali, Sabrina; Sritharan, Nanthara; Campani, Claudia; Gregory, Jules; Durand, François; Ganne-Carrié, Nathalie; Ronot, Maxime; Lévy, Vincent; Nault, Jean-Charles. - In: JHEP REPORTS. - ISSN 2589-5559. - STAMPA. - (2023), pp. 0-0. [10.1016/j.jhepr.2023.100755]
Fragility index of positive phase II and III randomized clinical trials of treatments for hepatocellular carcinoma (2002-2022)
Campani, Claudia;
2023
Abstract
The fragility index is a method to assess robustness of a clinical trial and is defined the minimum number of best survivors reassigned to the control group required to revert the statistically significant result of a clinical trial to non-significant. Among 25 randomized controlled trials in HCC, the median fragility index was 5 and ten trials among 25 (40%) had a fragility index of 2 or less indicating an important fragility.
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