Background and aim: In recent decades, obesity prevalence has reached epidemic proportions and considering the pivotal role of gut microbiota (GM) in the regulation of energy balance, alternative non-pharmacological approaches involving probiotics’ administration have been proposed. The aim of the present study was to evaluate the effect of Lactiplantibacillus plantarum IMC 510® supplementation on anthropometric and biochemical parameters, GM composition and functionality, and gastrointestinal and general symptoms of overweight/obese subjects. Methods: Forty overweight/obese subjects were randomly assigned to daily consume the probiotic Lactiplantibacillus plantarum IMC 510® or placebo for 3 months. Before and after the administration period, anthropometric and biochemical parameters, self-administered questionnaires, and plasma and stool samples were obtained from each participant. The GM characterization was performed with 16S rRNA sequencing, while fecal short (SCFAs) and medium (MCFAs) chain fatty acids were analyzed with a gas chromatography–mass spectrometry protocol. Results: Compared to placebo, probiotic supplementation determined a significant decrease in body weight, BMI, waist circumference, waist-to-height ratio, and blood glucose. Moreover, probiotic administration produced a significant decrease of the genera Hafnia-Obesumbacterium and Romboutsia and an increase of Succiniclasticum spp.; conversely, placebo administration resulted in the decrease of Actinomycetaceae and an increase of both Alloprevotella spp. and of the levels of pro-inflammatory hexanoic and heptanoic acids. Conclusion: Thanks to its effect in increasing some beneficial gut bacteria and lowering effects on waist circumference, fasting glucose levels and gastrointestinal symptoms of obese subjects, Lactiplantibacillus plantarum IMC 510® supplementation could represent a future and encouraging strategy for the prevention or treatment of obesity.

Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects / Pagliai, Giuditta; Coman, Maria Magdalena; Baldi, Simone; Dinu, Monica; Nannini, Giulia; Russo, Edda; Curini, Lavinia; Colombini, Barbara; Lotti, Sofia; Pallecchi, Marco; Di Gloria, Leandro; Bartolucci, Gianluca; Ramazzotti, Matteo; Verdenelli, Maria Cristina; Sofi, Francesco; Amedei, Amedeo. - In: FRONTIERS IN NUTRITION. - ISSN 2296-861X. - STAMPA. - 10:(2023), pp. 1142527-1142537. [10.3389/fnut.2023.1142527]

Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects

Pagliai, Giuditta
Writing – Original Draft Preparation
;
Baldi, Simone
Writing – Original Draft Preparation
;
Dinu, Monica
Investigation
;
Nannini, Giulia
Investigation
;
Russo, Edda
Investigation
;
Curini, Lavinia
Formal Analysis
;
Colombini, Barbara
Writing – Review & Editing
;
Lotti, Sofia
Investigation
;
Pallecchi, Marco;Di Gloria, Leandro
Investigation
;
Bartolucci, Gianluca;Ramazzotti, Matteo
Formal Analysis
;
Sofi, Francesco
Writing – Review & Editing
;
Amedei, Amedeo
Writing – Review & Editing
2023

Abstract

Background and aim: In recent decades, obesity prevalence has reached epidemic proportions and considering the pivotal role of gut microbiota (GM) in the regulation of energy balance, alternative non-pharmacological approaches involving probiotics’ administration have been proposed. The aim of the present study was to evaluate the effect of Lactiplantibacillus plantarum IMC 510® supplementation on anthropometric and biochemical parameters, GM composition and functionality, and gastrointestinal and general symptoms of overweight/obese subjects. Methods: Forty overweight/obese subjects were randomly assigned to daily consume the probiotic Lactiplantibacillus plantarum IMC 510® or placebo for 3 months. Before and after the administration period, anthropometric and biochemical parameters, self-administered questionnaires, and plasma and stool samples were obtained from each participant. The GM characterization was performed with 16S rRNA sequencing, while fecal short (SCFAs) and medium (MCFAs) chain fatty acids were analyzed with a gas chromatography–mass spectrometry protocol. Results: Compared to placebo, probiotic supplementation determined a significant decrease in body weight, BMI, waist circumference, waist-to-height ratio, and blood glucose. Moreover, probiotic administration produced a significant decrease of the genera Hafnia-Obesumbacterium and Romboutsia and an increase of Succiniclasticum spp.; conversely, placebo administration resulted in the decrease of Actinomycetaceae and an increase of both Alloprevotella spp. and of the levels of pro-inflammatory hexanoic and heptanoic acids. Conclusion: Thanks to its effect in increasing some beneficial gut bacteria and lowering effects on waist circumference, fasting glucose levels and gastrointestinal symptoms of obese subjects, Lactiplantibacillus plantarum IMC 510® supplementation could represent a future and encouraging strategy for the prevention or treatment of obesity.
2023
10
1142527
1142537
Goal 3: Good health and well-being
Pagliai, Giuditta; Coman, Maria Magdalena; Baldi, Simone; Dinu, Monica; Nannini, Giulia; Russo, Edda; Curini, Lavinia; Colombini, Barbara; Lotti, Sofia; Pallecchi, Marco; Di Gloria, Leandro; Bartolucci, Gianluca; Ramazzotti, Matteo; Verdenelli, Maria Cristina; Sofi, Francesco; Amedei, Amedeo
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1305331
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