To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the "deep water". This journal is
Catechols: A new class of carbonic anhydrase inhibitors / D'Ambrosio K.; Carradori S.; Cesa S.; Angeli A.; Monti S.M.; Supuran C.T.; De Simone G.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - ELETTRONICO. - 56:(2020), pp. 13033-13036. [10.1039/d0cc05172a]
Catechols: A new class of carbonic anhydrase inhibitors
Angeli A.;Supuran C. T.;
2020
Abstract
To date, catechols have been only poorly investigated as carbonic anhydrase (CA) inhibitors. Here we report the first structural information on the CA inhibition mechanism of these molecules, showing that they adopt a peculiar binding mode to the enzyme active site which involves the zinc-bound water molecule and the "deep water". This journal is
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