Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.

Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis / Bettiol, Alessandra; Fagni, Filippo; Mattioli, Irene; Bagni, Giacomo; Vitiello, Gianfranco; Grassi, Alessia; Della Bella, Chiara; Benagiano, Marisa; Troilo, Arianna; Holownia, Katarzyna Stella; Simon, David; Argento, Flavia Rita; Sota, Jurgen; Fabiani, Claudia; Becatti, Matteo; Fiorillo, Claudia; Schett, Georg; Lopalco, Giuseppe; Cantarini, Luca; Prisco, Domenico; Silvestri, Elena; Emmi, Giacomo; D’Elios, Mario Milco. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - ELETTRONICO. - 24:(2023), pp. 8817-8817. [10.3390/ijms24108817]

Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis

Bettiol, Alessandra
Writing – Original Draft Preparation
;
Mattioli, Irene;Bagni, Giacomo;Grassi, Alessia;Della Bella, Chiara;Benagiano, Marisa;Troilo, Arianna;Holownia, Katarzyna Stella;Argento, Flavia Rita;Becatti, Matteo;Fiorillo, Claudia;Prisco, Domenico;Silvestri, Elena;Emmi, Giacomo;
2023

Abstract

Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.
2023
24
8817
8817
Bettiol, Alessandra; Fagni, Filippo; Mattioli, Irene; Bagni, Giacomo; Vitiello, Gianfranco; Grassi, Alessia; Della Bella, Chiara; Benagiano, Marisa; T...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1311000
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