PSICHE (NCT05022914) is a prospective trial to test a [Ga-68]Ga- PSMA-11 PET/CT imaging tailored strategy. All evaluable patients had biochemical relapse after surgery and underwent centralized [Ga-68]Ga-PSMA-11 PET/CT imaging. The treatment was performed according pre-defined criteria. Observation and re-staging at further PSA progression were proposed to patients with negative PSMA and previous postoperative RT. Prostate bed SRT was proposed to all patients with a negative staging or positive imaging within prostate bed. Stereotactic body radiotherapy (SBRT) to all sites of disease was used for all patients with pelvic nodal recurrence (nodal disease < 2 cm under aortic bifurcation) or oligometastatic disease. At 3 months after treatment, 54.7% of patients had a complete biochemical response Only 2 patients experienced G2 Genitourinary toxicity. No G2 Gastrointestinal toxicity was recorded. A PSMA targeted treatment strategy led to encouraging results and was well tolerated.

Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results / Francolini, Giulio; Ganovelli, Michele; Di Cataldo, Vanessa; Detti, Beatrice; Caini, Saverio; Loi, Mauro; Simontacchi, Gabriele; Desideri, Isacco; Greto, Daniela; Valzano, Marianna; Serni, Sergio; Vaggelli, Luca; Salvestrini, Viola; Visani, Luca; Becherini, Carlotta; Olmetto, Emanuela; Franzese, Ciro; Baldaccini, Davide; Scorsetti, Marta; Sollini, Martina; Chiti, Arturo; Meattini, Icro; Valicenti, Richard K; Livi, Lorenzo. - In: CLINICAL & EXPERIMENTAL METASTASIS. - ISSN 0262-0898. - ELETTRONICO. - 40:(2023), pp. 0-0. [10.1007/s10585-023-10204-y]

Early biochemical outcomes following PSMA guided approach for bIoCHEmical relapse after prostatectomy-PSICHE trial (NCT05022914): preliminary results

Francolini, Giulio;Ganovelli, Michele;Di Cataldo, Vanessa;Detti, Beatrice;Caini, Saverio;Loi, Mauro;Simontacchi, Gabriele;Desideri, Isacco;Greto, Daniela;Valzano, Marianna;Serni, Sergio;Vaggelli, Luca;Salvestrini, Viola;Visani, Luca;Becherini, Carlotta;Olmetto, Emanuela;Franzese, Ciro;Meattini, Icro;Livi, Lorenzo
2023

Abstract

PSICHE (NCT05022914) is a prospective trial to test a [Ga-68]Ga- PSMA-11 PET/CT imaging tailored strategy. All evaluable patients had biochemical relapse after surgery and underwent centralized [Ga-68]Ga-PSMA-11 PET/CT imaging. The treatment was performed according pre-defined criteria. Observation and re-staging at further PSA progression were proposed to patients with negative PSMA and previous postoperative RT. Prostate bed SRT was proposed to all patients with a negative staging or positive imaging within prostate bed. Stereotactic body radiotherapy (SBRT) to all sites of disease was used for all patients with pelvic nodal recurrence (nodal disease < 2 cm under aortic bifurcation) or oligometastatic disease. At 3 months after treatment, 54.7% of patients had a complete biochemical response Only 2 patients experienced G2 Genitourinary toxicity. No G2 Gastrointestinal toxicity was recorded. A PSMA targeted treatment strategy led to encouraging results and was well tolerated.
2023
40
0
0
Francolini, Giulio; Ganovelli, Michele; Di Cataldo, Vanessa; Detti, Beatrice; Caini, Saverio; Loi, Mauro; Simontacchi, Gabriele; Desideri, Isacco; Greto, Daniela; Valzano, Marianna; Serni, Sergio; Vaggelli, Luca; Salvestrini, Viola; Visani, Luca; Becherini, Carlotta; Olmetto, Emanuela; Franzese, Ciro; Baldaccini, Davide; Scorsetti, Marta; Sollini, Martina; Chiti, Arturo; Meattini, Icro; Valicenti, Richard K; Livi, Lorenzo
File in questo prodotto:
File Dimensione Formato  
10585_2023_Article_10204.pdf

Accesso chiuso

Tipologia: Pdf editoriale (Version of record)
Licenza: DRM non definito
Dimensione 824.12 kB
Formato Adobe PDF
824.12 kB Adobe PDF   Richiedi una copia

I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1339633
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact