TP53-altered myelodysplastic syndrome with excess blasts and TP53-altered acute myeloid leukemia should be considered under one unifying classification term for their study in clinical trials. Ultimately, such a unification would simplify the screening processes for clinical trials and allow a focus on treating the patient for a genetically defined disorder rather than one based on an arbitrary blast threshold.
TP53-altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be approached as a single entity / Shallis, Rory M; Daver, Naval G; Altman, Jessica K; Hasserjian, Robert P; Kantarjian, Hagop M; Platzbecker, Uwe; Santini, Valeria; Wei, Andrew H; Sallman, David A; Zeidan, Amer M. - In: CANCER. - ISSN 0008-543X. - ELETTRONICO. - 129:(2023), pp. 175-180. [10.1002/cncr.34535]
TP53-altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be approached as a single entity
Santini, Valeria;
2023
Abstract
TP53-altered myelodysplastic syndrome with excess blasts and TP53-altered acute myeloid leukemia should be considered under one unifying classification term for their study in clinical trials. Ultimately, such a unification would simplify the screening processes for clinical trials and allow a focus on treating the patient for a genetically defined disorder rather than one based on an arbitrary blast threshold.
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Cancer - 2022 - Shallis - TP53%E2%80%90altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be.pdf
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