Objectives: Respiratory syncytial virus (RSV) is a frequent cause of acute lower respiratory infection in children, imposing a substantial economic burden on healthcare systems. This systematic review aimed to assess the economic burden and healthcare utilisation of RSV in children aged 0-59 months in Italy. Study design: Systematic review. Methods: A systematic search of PubMed, Embase, Scopus, and the International HTA Database, including studies published in English or Italian, was conducted between January 2000 and July 2022. Inclusion criteria required studies to be conducted in Italy and provide data on the economic costs and healthcare resource utilisation related to RSV infections. Results: Out of 20,845 records screened, 18 articles met the inclusion criteria. Only one study provided comprehensive data on RSV disease costs, including hospitalisation, diagnostic tests, and medical procedures for infants with RSV-bronchiolitis. The mean cost per inpatient was higher for RSV-positive children (€5753.43 ± €2041.62) than that for RSV-negative children. Additionally, five studies reported a median length of hospital stay of 5 days for RSV-infected children, and four studies indicated a higher frequency of intensive care unit admissions for RSV-infected children than for those with other viral infections. Conclusions: This is the first systematic review to examine the economic burden and healthcare utilisation of RSV in children aged 0-59 months in Italy. While limited data were available, the findings underscore the urgency to conduct further research and gather additional evidence on the costs and healthcare resource utilisation associated with RSV infections. Such efforts are essential for informing the development of effective prevention strategies for paediatric RSV infections in Italy.
Costs and healthcare utilisation due to respiratory syncytial virus disease in paediatric patients in Italy: a systematic review / Angela Bechini; Cristina Salvati; Benedetta Bonito; Marco Del Riccio; Enrica Stancanelli; Mario Bruschi; Giulia Ionita; Johanna Alexandra Iamarino; Davide Bentivegna; Primo Buscemi; Giulia Ciardi; Claudia Cosma; Lorenzo Stacchini; Cristiana Conticello; Manjola Bega; Sonia Paoli; Annamaria Schirripa; Lorenzo Bertizzolo; Barbara Muzii; Maria Vittoria Azzi; Salvatore Parisi; Francesca Trippi; Paolo Bonanni; Sara Boccalini. - In: PUBLIC HEALTH. - ISSN 0033-3506. - ELETTRONICO. - 227:(2024), pp. 103-111. [10.1016/j.puhe.2023.11.039]
Costs and healthcare utilisation due to respiratory syncytial virus disease in paediatric patients in Italy: a systematic review
Angela Bechini;Cristina Salvati;Benedetta Bonito;Marco Del Riccio
;Enrica Stancanelli;Mario Bruschi;Giulia Ionita;Johanna Alexandra Iamarino;Davide Bentivegna;Primo Buscemi;Giulia Ciardi;Claudia Cosma;Lorenzo Stacchini;Cristiana Conticello;Manjola Bega;Sonia Paoli;Annamaria Schirripa;Paolo Bonanni;Sara Boccalini
2024
Abstract
Objectives: Respiratory syncytial virus (RSV) is a frequent cause of acute lower respiratory infection in children, imposing a substantial economic burden on healthcare systems. This systematic review aimed to assess the economic burden and healthcare utilisation of RSV in children aged 0-59 months in Italy. Study design: Systematic review. Methods: A systematic search of PubMed, Embase, Scopus, and the International HTA Database, including studies published in English or Italian, was conducted between January 2000 and July 2022. Inclusion criteria required studies to be conducted in Italy and provide data on the economic costs and healthcare resource utilisation related to RSV infections. Results: Out of 20,845 records screened, 18 articles met the inclusion criteria. Only one study provided comprehensive data on RSV disease costs, including hospitalisation, diagnostic tests, and medical procedures for infants with RSV-bronchiolitis. The mean cost per inpatient was higher for RSV-positive children (€5753.43 ± €2041.62) than that for RSV-negative children. Additionally, five studies reported a median length of hospital stay of 5 days for RSV-infected children, and four studies indicated a higher frequency of intensive care unit admissions for RSV-infected children than for those with other viral infections. Conclusions: This is the first systematic review to examine the economic burden and healthcare utilisation of RSV in children aged 0-59 months in Italy. While limited data were available, the findings underscore the urgency to conduct further research and gather additional evidence on the costs and healthcare resource utilisation associated with RSV infections. Such efforts are essential for informing the development of effective prevention strategies for paediatric RSV infections in Italy.File | Dimensione | Formato | |
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