DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy

Micheli, L.; Rajamoni, J.; Di Cesare Mannelli, L.; Rajagopalan, P.; Ghelardini, C.; Rajagopalan, R.

doi:10.1016/j.bmcl.2023.129472

Diabetic neuropathy (DN) is a painful, chronic ailment that affects a large segment of diabetic population worldwide. Current medications such as pregabalin or duloxetine treat only the pain symptom associated with DN, but not the underlying nerve damage. DDD-028 (1) is a small molecule that displays potent pain-relieving activity in streptozotocin (STZ)-induced rodent model of DN. Combined with other studies indicating that DDD-028 suppresses astrogliosis and nerve damage induced by the anti-cancer drug, paclitaxel, the present study suggests that DDD-028 would be useful as a disease modifying therapeutic in the treatment of DN. The 3-dimensional structure of DDD-028 was confirmed by single crystal X-ray crystallography.

DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy / Micheli L.; Rajamoni J.; Di Cesare Mannelli L.; Rajagopalan P.; Ghelardini C.; Rajagopalan R.. - In: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. - ISSN 1464-3405. - ELETTRONICO. - 95:(2023), pp. 129472.0-129472.0. [10.1016/j.bmcl.2023.129472]