Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.
CALR mutation burden in essential thrombocythemia and disease outcome / Guglielmelli, Paola; Szuber, Natasha; Gangat, Naseema; Capecchi, Giulio; Maccari, Chiara; Harnois, Michaël; Karrar, Omer; Abdelmagid, Maymona; Balliu, Manjola; Nacca, Elena; Atanasio, Alessandro; Sestini, Ilaria; Désilets, Audrey; Loscocco, Giuseppe Gaetano; Rotunno, Giada; Busque, Lambert; Tefferi, Ayalew; Vannucchi, Alessandro Maria. - In: BLOOD. - ISSN 1528-0020. - ELETTRONICO. - 143:(2024), pp. 1310-1314. [10.1182/blood.2023023428]
CALR mutation burden in essential thrombocythemia and disease outcome
Guglielmelli, PaolaWriting – Original Draft Preparation
;Capecchi, GiulioData Curation
;Maccari, ChiaraFormal Analysis
;Balliu, ManjolaFormal Analysis
;Nacca, ElenaFormal Analysis
;Atanasio, AlessandroData Curation
;Sestini, IlariaFormal Analysis
;Loscocco, Giuseppe GaetanoWriting – Review & Editing
;Rotunno, GiadaWriting – Review & Editing
;Vannucchi, Alessandro MariaWriting – Original Draft Preparation
2024
Abstract
Among 281 patients with essential thrombocythemia and calreticulin (CALR) mutation, we found a variant allele frequency of ≥60% to be associated with significantly shortened myelofibrosis-free survival, mostly apparent with CALR type-1 and CALR type-indeterminate mutations.
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