: A severe outbreak of influenza A(H1N1pdm09) infection in seven children (median age: 52 months) occurred between December 2023 and January 2024 in Tuscany, Italy. Clinical presentation ranged from milder encephalopathy to acute necrotizing encephalopathy (ANE) with coma and multiorgan failure; one child died. This report raises awareness for clinicians to identify and treat early acute encephalopathy caused by H1N1 influenza and serves as a reminder of severe presentations of influenza in young children and the importance of vaccination.
Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024 / Bartolini, L., Ricci, S., Azzari, C., Moriondo, M., Nieddu, F., L'Erario, M., Ricci, Z., Simonini, G., Mortilla, M., Indolfi, G., Montagnani, C., Chiappini, E., Galli, L., Guerrini, R.. - In: EUROSURVEILLANCE. - ISSN 1560-7917. - ELETTRONICO. - 29:(2024), pp. 0-0. [10.2807/1560-7917.ES.2024.29.17.2400199]
Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024
Bartolini, Luca;Ricci, Silvia;Azzari, Chiara;Moriondo, Maria;Nieddu, Francesco;L'Erario, Manuela;Ricci, Zaccaria;Simonini, Gabriele;Mortilla, Marzia;Indolfi, Giuseppe;Montagnani, Carlotta;Chiappini, Elena;Galli, Luisa;Guerrini, Renzo
2024
Abstract
: A severe outbreak of influenza A(H1N1pdm09) infection in seven children (median age: 52 months) occurred between December 2023 and January 2024 in Tuscany, Italy. Clinical presentation ranged from milder encephalopathy to acute necrotizing encephalopathy (ANE) with coma and multiorgan failure; one child died. This report raises awareness for clinicians to identify and treat early acute encephalopathy caused by H1N1 influenza and serves as a reminder of severe presentations of influenza in young children and the importance of vaccination.
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