Clinical studies indicate that Arthrospira platensis (A. platensis) mitigates cardiometabolic risk factors, but the underlying mechanisms are very elusive. To fill this gap, Sprague-Dowley rats were fed either AIN-76 normal diet (5 % corn oil) or high-fat (HF; 30 % lard + 3 % corn oil) or HF + 5 % A. platensis F&M-C256 diet for 3 months. A. platensis F&M-C256 decreased blood triglycerides and total cholesterol, systolic and diastolic pressure and enhanced the expression of thermogenesis-related genes Prdm16, Dio2, PPARγ, Ucp1 and Lpl in visceral adipose tissue, compared to HF-diet. A. platensis reduced ANGPTL3 plasma levels and hepatic steatosis, prevented periaortic adipose tissue hypertrophy and increased aortic eNOS expression. These data provide some mechanistic evidence about the beneficial effects of A. platensis observed in human studies. Further controlled trials are needed to verify the clinical usefulness of A. platensis supplementation against metabolic disorders, to select the dosing regimens and the subgroup of patients with likelihood of benefit.

Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet / Mario D'Ambrosio, Elisabetta Bigagli, Lorenzo Cinci, Gianluca Cipriani, Alberto Niccolai, Natascia Biondi, Liliana Rodolfi, Francesca Zambelli, Manuela Gencarelli, Annunziatina Laurino, Laura Raimondi, Mario R. Tredici, Cristina Luceri. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - ELETTRONICO. - 116:(2024), pp. 106150.1-106150.8. [10.1016/j.jff.2024.106150]

Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet

Mario D'Ambrosio;Elisabetta Bigagli
;
Lorenzo Cinci;Gianluca Cipriani;Natascia Biondi;Liliana Rodolfi;Francesca Zambelli;Manuela Gencarelli;Annunziatina Laurino;Laura Raimondi;Mario R. Tredici;Cristina Luceri
2024

Abstract

Clinical studies indicate that Arthrospira platensis (A. platensis) mitigates cardiometabolic risk factors, but the underlying mechanisms are very elusive. To fill this gap, Sprague-Dowley rats were fed either AIN-76 normal diet (5 % corn oil) or high-fat (HF; 30 % lard + 3 % corn oil) or HF + 5 % A. platensis F&M-C256 diet for 3 months. A. platensis F&M-C256 decreased blood triglycerides and total cholesterol, systolic and diastolic pressure and enhanced the expression of thermogenesis-related genes Prdm16, Dio2, PPARγ, Ucp1 and Lpl in visceral adipose tissue, compared to HF-diet. A. platensis reduced ANGPTL3 plasma levels and hepatic steatosis, prevented periaortic adipose tissue hypertrophy and increased aortic eNOS expression. These data provide some mechanistic evidence about the beneficial effects of A. platensis observed in human studies. Further controlled trials are needed to verify the clinical usefulness of A. platensis supplementation against metabolic disorders, to select the dosing regimens and the subgroup of patients with likelihood of benefit.
2024
116
1
8
Mario D'Ambrosio, Elisabetta Bigagli, Lorenzo Cinci, Gianluca Cipriani, Alberto Niccolai, Natascia Biondi, Liliana Rodolfi, Francesca Zambelli, Manuel...espandi
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/1362113
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