SARS-CoV-2 encodes the N protein, a genetically stable and highly expressed structural protein essential for organizing the ribonucleoprotein complex. N is composed of structured domains (NTD and CTD) and three intrinsically disordered regions (IDRs). This study aims to characterize the full-length (FL) N protein and its interaction with RNA, comparing it with simpler constructs (NTD, NTR). Carbon-13 NMR is crucial for analyzing IDRs within complex protein systems.
EXPRESSION OF NUCLEOCAPSID PROTEIN (N) FROM SARS-CoV 2 AND ITS CHARACTERIZATION THROUGH HIGH-FIELD NMR SPECTROSCOPY / Tessa Bolognesi, Marco Schiavina, Letizia Pontoriero, Isabella C. Felli, Roberta Pierattelli. - ELETTRONICO. - (2023), pp. 1-1. (Intervento presentato al convegno 50th National Congress GIDRM).
EXPRESSION OF NUCLEOCAPSID PROTEIN (N) FROM SARS-CoV 2 AND ITS CHARACTERIZATION THROUGH HIGH-FIELD NMR SPECTROSCOPY
Tessa Bolognesi;Marco Schiavina;Letizia Pontoriero;Isabella C. Felli;Roberta Pierattelli
2023
Abstract
SARS-CoV-2 encodes the N protein, a genetically stable and highly expressed structural protein essential for organizing the ribonucleoprotein complex. N is composed of structured domains (NTD and CTD) and three intrinsically disordered regions (IDRs). This study aims to characterize the full-length (FL) N protein and its interaction with RNA, comparing it with simpler constructs (NTD, NTR). Carbon-13 NMR is crucial for analyzing IDRs within complex protein systems.
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