The SARS-CoV-2 N protein is highly expressed and genetically stable, making it a key antiviral target. It contains structured domains and three intrinsically disordered regions (IDRs). Using NMR, especially 13C detection, this study investigates RNA interactions across different N constructs, focusing on the role of IDRs. The flexible IDRs remain detectable in full-length protein, enabling comparison with shorter constructs like NTR and NTD.
EXPRESSION OF THE NUCLEOCAPSID PROTEIN (N) FROM SARS-CoV 2 AND ITS CHARACTERIZATION THROUGH HIGH-FIELD NMR SPECTROSCOPY / Tessa Bolognesi, Marco Schiavina, Letizia Pontoriero, Isabella C. Felli, Roberta Pierattelli. - ELETTRONICO. - (2024), pp. 1-2. ( Advanced Isotopic Labelling Methods Congress 2024).
EXPRESSION OF THE NUCLEOCAPSID PROTEIN (N) FROM SARS-CoV 2 AND ITS CHARACTERIZATION THROUGH HIGH-FIELD NMR SPECTROSCOPY
Tessa Bolognesi;Marco Schiavina;Letizia Pontoriero;Isabella C. Felli;Roberta Pierattelli
2024
Abstract
The SARS-CoV-2 N protein is highly expressed and genetically stable, making it a key antiviral target. It contains structured domains and three intrinsically disordered regions (IDRs). Using NMR, especially 13C detection, this study investigates RNA interactions across different N constructs, focusing on the role of IDRs. The flexible IDRs remain detectable in full-length protein, enabling comparison with shorter constructs like NTR and NTD.
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