High-resolution solution NMR is employed here to investigate the structure of alpha-synuclein aggregates using hydrogen-deuterium exchange coupled with NMR experiments. This approach can also be applied to the structural analysis of aggregates derived from patient samples using the seed amplification assay (SAA).
DELEVELOPMENT OF NMR METHODOLOGIES FOR FINGERPRINTING OF NEUROLOGICAL DISEASES: ALPHA-SYNUCLEIN AS A CASE STUDY / Linda Cerofolini, Arianna Ciullini, Merve Begum Bacinoglu, Annalisa Lombardo, Rachele Domina, Floriana Bellandi, Alice Russotto, Sara Adriana Della Seta, Valentina Margiotta, Tommaso Staderini, Bianca Susini, Gianfranco Gaudiano, Roberta Telese, Fabiana Colucci, Alessia Catania, Valentina Leta, Riccardo Pascuzzo, Federico Angelo Cazzaniga, Claudia Saraceno, Samanta Mazzetti, Sara Maria Silvia Portaleone, Roberto Cilia, Antonio Emanuele Elia, Grazia Devigili, Pietro Tiraboschi, Marco Fragai, Fabio Moda. - ELETTRONICO. - (2025), pp. 48-48. ( "Protein misfolding and aggregation in disease" Mantova ).
DELEVELOPMENT OF NMR METHODOLOGIES FOR FINGERPRINTING OF NEUROLOGICAL DISEASES: ALPHA-SYNUCLEIN AS A CASE STUDY
Linda Cerofolini;Tommaso Staderini;Bianca Susini;Marco Fragai;
2025
Abstract
High-resolution solution NMR is employed here to investigate the structure of alpha-synuclein aggregates using hydrogen-deuterium exchange coupled with NMR experiments. This approach can also be applied to the structural analysis of aggregates derived from patient samples using the seed amplification assay (SAA).
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