High-resolution solution NMR is employed here to investigate the structure of alpha-synuclein aggregates using hydrogen-deuterium exchange coupled with NMR experiments. This approach can also be applied to the structural analysis of aggregates derived from patient samples using the seed amplification assay (SAA).
DELEVELOPMENT OF NMR METHODOLOGIES FOR FINGERPRINTING OF NEUROLOGICAL DISEASES: ALPHA-SYNUCLEIN AS A CASE STUDY / Linda Cerofolini, A.C.. - ELETTRONICO. - (2025), pp. 48-48. ("Protein misfolding and aggregation in disease" Mantova ).
DELEVELOPMENT OF NMR METHODOLOGIES FOR FINGERPRINTING OF NEUROLOGICAL DISEASES: ALPHA-SYNUCLEIN AS A CASE STUDY
Linda Cerofolini;Tommaso Staderini;Bianca Susini;Marco Fragai;
2025
Abstract
High-resolution solution NMR is employed here to investigate the structure of alpha-synuclein aggregates using hydrogen-deuterium exchange coupled with NMR experiments. This approach can also be applied to the structural analysis of aggregates derived from patient samples using the seed amplification assay (SAA).
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