Disposable and versatile optical sensors for SERS analysis of liquid samples by fiber-based spectroscopy

Optical detection techniques based on surface enhanced Raman spectroscopy (SERS) can provide relevant information on molecular and protein composition of biological samples, thus enabling to discriminate between physiological and pathological conditions. With the attempt to develop point-of-impact diagnostics devices, in this study we combine low-cost fabrication processes with surface functionalization strategies for the fabrication of SERS-active polymeric substrates engineered to selectively detect specific biomarkers. By reversibly coupling these devices with the distal end of portable Raman instruments, SERS measurements could be potentially implemented for the early diagnosis of widespread pathologies by SERS analysis of liquid biopsies.