This work unveils a GLO1-dependent pathway as a key contributor to lactate-mediated H3K18la and its downstream transcriptional outputs, highlighting histone lactylation as a metabolically driven regulator of prostate cancer progression and as a potential target for therapeutic intervention in lactate-enriched TME.
Lactate-induced H3K18 lactylation drives prostate cancer aggressiveness through a GLO1-dependent lactyl-GSH pathway / Giulia Gangarossa. - (2026).
Lactate-induced H3K18 lactylation drives prostate cancer aggressiveness through a GLO1-dependent lactyl-GSH pathway
Giulia GangarossaWriting – Original Draft Preparation
2026
Abstract
This work unveils a GLO1-dependent pathway as a key contributor to lactate-mediated H3K18la and its downstream transcriptional outputs, highlighting histone lactylation as a metabolically driven regulator of prostate cancer progression and as a potential target for therapeutic intervention in lactate-enriched TME.
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