The favorable CEST properties of NDTA arise from its unique structure. Monoprotonation of 1,8-dialkylamino naphthalenes forms a highly stable intramolecular [N–H–N]⁺ hydrogen bridge, causing an extreme downfield shift of the slowly exchanging proton. The acetate sidearms enhance kex via intramolecular catalysis of the proton exchange. Additionally, NDTA forms a weak Ca(II)-complex whose pH-dependent formation/dissociation imparts pH sensitivity to the CEST effect. The new diaCEST agent NDTA combines large Δω and nearly optimal kex for in vivo imaging at clinical B0 field.
NDTA : Novel DiaCEST Agent with Strongly Shifted Exchanging Protons / Madalina Ranga. - ELETTRONICO. - (2026), pp. 0-0. (FC-RELAX : Third Joint Event – Multidisciplinary Research Workshop. Rostock ).
NDTA : Novel DiaCEST Agent with Strongly Shifted Exchanging Protons
Madalina Ranga
2026
Abstract
The favorable CEST properties of NDTA arise from its unique structure. Monoprotonation of 1,8-dialkylamino naphthalenes forms a highly stable intramolecular [N–H–N]⁺ hydrogen bridge, causing an extreme downfield shift of the slowly exchanging proton. The acetate sidearms enhance kex via intramolecular catalysis of the proton exchange. Additionally, NDTA forms a weak Ca(II)-complex whose pH-dependent formation/dissociation imparts pH sensitivity to the CEST effect. The new diaCEST agent NDTA combines large Δω and nearly optimal kex for in vivo imaging at clinical B0 field.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Abstr_Rostock_2026_RangaMadalina_.docx
accesso aperto
Tipologia:
Pdf editoriale (Version of record)
Licenza:
Open Access
Dimensione
334.88 kB
Formato
Microsoft Word XML
|
334.88 kB | Microsoft Word XML |
I documenti in FLORE sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
