PET imaging with manganese-52 enables long-duration visualization of biological processes. This work compares manganese(II) complexes of the macrocyclic chelators PYAN and CHXPYAN, showing that the CHXPYAN complex has markedly higher kinetic inertness and improved in vivo stability. These findings support CHXPYAN as a promising chelator for the development of manganese-52-based PET radiopharmaceuticals.
ENHANCING IN VIVO STABILITY OF [52Mn]Mn(II) MACROCYCLIC COMPLEXES FOR PET APPLICATION / madalina ranga. - ELETTRONICO. - (2026), pp. 0-0. (46th International Conference on Coordination Chemistry ).
ENHANCING IN VIVO STABILITY OF [52Mn]Mn(II) MACROCYCLIC COMPLEXES FOR PET APPLICATION
madalina ranga
2026
Abstract
PET imaging with manganese-52 enables long-duration visualization of biological processes. This work compares manganese(II) complexes of the macrocyclic chelators PYAN and CHXPYAN, showing that the CHXPYAN complex has markedly higher kinetic inertness and improved in vivo stability. These findings support CHXPYAN as a promising chelator for the development of manganese-52-based PET radiopharmaceuticals.
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