The current study was designed to investigate the number and affinity of plateletthromboxane A2/prostaglandinH2 () receptors in patients with unstableangina and, if any, the role played by the increasedthrombinformation that is a common finding in these patients. Measurements taken during activeunstableangina but not those taken during inactive angina showed an increasednumber (p < 0.001), without changes in affinity, of plateletreceptors, evaluated as the binding capacity of iodine 125PTAOH, a stable TxA2 analogue. Moreover patients with activeangina had higher plasma concentrations of fibrinopeptide A (FPA) (p < 0.0001), which were significantly related to the number of plateletreceptors (r = 0.76; p < 0.01) Heparin infusion but not aspirin treatment promptly normalized the number of receptors and significantly reduced plasma FPA concentrations. In an in-vitro study thrombin in a concentration similar to that found in vivo significantly increased the number of plateletreceptors (p < 0.01), whereas heparin did not affect receptors. These results have important therapeutic implications and indicate the preferential use of heparin rather than aspirin during the acute phase of unstableangina.

Increased number of thromboxane A2-prostaglandin H2 platelet receptors in active unstable angina and causative role of enhanced thrombin formation / P.A.MODESTI; COLELLA A; CECIONI I; COSTOLI A; BIAGINI D; MIGLIORINI A; NERI SERNERI GG. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - STAMPA. - 129:(1995), pp. 873-879. [10.1016/0002-8703(95)90106-X]

Increased number of thromboxane A2-prostaglandin H2 platelet receptors in active unstable angina and causative role of enhanced thrombin formation.

MODESTI, PIETRO AMEDEO;CECIONI, ILARIA;NERI SERNERI, GIAN GASTONE
1995

Abstract

The current study was designed to investigate the number and affinity of plateletthromboxane A2/prostaglandinH2 () receptors in patients with unstableangina and, if any, the role played by the increasedthrombinformation that is a common finding in these patients. Measurements taken during activeunstableangina but not those taken during inactive angina showed an increasednumber (p < 0.001), without changes in affinity, of plateletreceptors, evaluated as the binding capacity of iodine 125PTAOH, a stable TxA2 analogue. Moreover patients with activeangina had higher plasma concentrations of fibrinopeptide A (FPA) (p < 0.0001), which were significantly related to the number of plateletreceptors (r = 0.76; p < 0.01) Heparin infusion but not aspirin treatment promptly normalized the number of receptors and significantly reduced plasma FPA concentrations. In an in-vitro study thrombin in a concentration similar to that found in vivo significantly increased the number of plateletreceptors (p < 0.01), whereas heparin did not affect receptors. These results have important therapeutic implications and indicate the preferential use of heparin rather than aspirin during the acute phase of unstableangina.
1995
129
873
879
P.A.MODESTI; COLELLA A; CECIONI I; COSTOLI A; BIAGINI D; MIGLIORINI A; NERI SERNERI GG
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/213789
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