ABSTRACT. In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesis
The effect of Linomide on the migration and proliferation of capillary endothelial cells elicited by vascular endothelial growth factor / A. PARENTI; S. DONNINI; L. MORBIDELLI; H.J. GRANGER; M. ZICHE. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 119:(1996), pp. 619-621.
The effect of Linomide on the migration and proliferation of capillary endothelial cells elicited by vascular endothelial growth factor
PARENTI, ASTRID;
1996
Abstract
ABSTRACT. In order to assess the mechanism of action of the quinoline-3-carboxyamide linomide as an antiangiogenic drug, the effect of linomide was studied in vitro on postcapillary endothelial cells exposed to vascular endothelial growth factor (VEGF). Linomide did not block the spontaneous replication of endothelial cells, but significantly suppressed endothelial cell growth and migration elicited by VEGF. It is concluded that linomide appears to be an effective tool to inhibit VEGF-dependent angiogenesisFile | Dimensione | Formato | |
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