FLORE (FLOrence REsearch) è il repository istituzionale ad accesso pieno e aperto dell'Università degli Studi di Firenze.
Raccoglie, documenta e conserva le informazioni sulla produzione scientifica dell'Università e costituisce l'Anagrafe della ricerca dell'Ateneo.
EnglishABSTRACT. We investigated the effects of metastasis, surgery and chemotherapy on both circulating dendritic cells (DCs) and monocyte-derived-DCs (MoDCs) in colorectal cancer (CRC) patients. Metastatic or nonmetastatic CRC patients had significantly reduced DC subsets compared to healthy subjects (p<0.001). These cells were significantly higher in metastatic than in nonmetastatic patients. MoDCs were significantly lower in metastatic than healthy and nonmetastatic subjects (p<0.001). Surgically treated patients had nearly one-half circulating DC subsets compared to healthy subjects (p<0.001) while no difference was found between unoperated and healthy subjects. MoDCs obtained from tumor-bearing were significantly higher than in operated subjects. In both cases, MoDCs were significantly lower than in healthy subjects (p<0.001) Circulating DCs and MoDCs were significantly lower in CRC patients, with or without chemotherapy, compared to healthy subjects (p<0.001). Compared to untreated, chemotherapy- treated patients had 30% fewer DC subsets and lower MoDCs. Characterization of circulating DC subsets and MoDCs may elucidate CRC patients’ immune system status.
http://hdl.handle.net/2158/24584| Titolo: | ROLE OF CONVENTIONAL TREATMENTS ON CIRCULATING AND MONOCYTE-DERIVED DENDRITIC CELLS IN COLORECTAL CANCER |
| Autori interni: | GERLINI, GIANNI PARENTI, ASTRID LEDDA, FABRIZIO PIMPINELLI, NICOLA NERI, BRUNO PANTALONE, DESIRE' |
| Autori: | L. BELLIK; G. GERLINI; A. PARENTI; F. LEDDA; N. PIMPINELLI; B. NERI; D. PANTALONE |
| Data di pubblicazione: | 2006 |
| Rivista: | CLINICAL IMMUNOLOGY |
| Volume: | 121(1) |
| Pagina iniziale: | 74 |
| Pagina finale: | 80 |
| Abstract: | ABSTRACT. We investigated the effects of metastasis, surgery and chemotherapy on both circulating dendritic cells (DCs) and monocyte-derived-DCs (MoDCs) in colorectal cancer (CRC) patients. Metastatic or nonmetastatic CRC patients had significantly reduced DC subsets compared to healthy subjects (p<0.001). These cells were significantly higher in metastatic than in nonmetastatic patients. MoDCs were significantly lower in metastatic than healthy and nonmetastatic subjects (p<0.001). Surgically treated patients had nearly one-half circulating DC subsets compared to healthy subjects (p<0.001) while no difference was found between unoperated and healthy subjects. MoDCs obtained from tumor-bearing were significantly higher than in operated subjects. In both cases, MoDCs were significantly lower than in healthy subjects (p<0.001) Circulating DCs and MoDCs were significantly lower in CRC patients, with or without chemotherapy, compared to healthy subjects (p<0.001). Compared to untreated, chemotherapy- treated patients had 30% fewer DC subsets and lower MoDCs. Characterization of circulating DC subsets and MoDCs may elucidate CRC patients’ immune system status. |
| Handle: | http://hdl.handle.net/2158/24584 |
| Appare nelle tipologie: | 1a - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Dimensione | Formato | Tipologia | Licenza | |
|---|---|---|---|---|---|---|
| dendritic cells.pdf | 204.97 kB | Adobe PDF | Versione Finale Referata | Administrator |
Copyright © 2017