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EnglishABSTRACT. We investigated the effects of metastasis, surgery and chemotherapy on both circulating dendritic cells (DCs) and monocyte-derived-DCs (MoDCs) in colorectal cancer (CRC) patients. Metastatic or nonmetastatic CRC patients had significantly reduced DC subsets compared to healthy subjects (p<0.001). These cells were significantly higher in metastatic than in nonmetastatic patients. MoDCs were significantly lower in metastatic than healthy and nonmetastatic subjects (p<0.001). Surgically treated patients had nearly one-half circulating DC subsets compared to healthy subjects (p<0.001) while no difference was found between unoperated and healthy subjects. MoDCs obtained from tumor-bearing were significantly higher than in operated subjects. In both cases, MoDCs were significantly lower than in healthy subjects (p<0.001) Circulating DCs and MoDCs were significantly lower in CRC patients, with or without chemotherapy, compared to healthy subjects (p<0.001). Compared to untreated, chemotherapy- treated patients had 30% fewer DC subsets and lower MoDCs. Characterization of circulating DC subsets and MoDCs may elucidate CRC patients’ immune system status.
| Titolo: | ROLE OF CONVENTIONAL TREATMENTS ON CIRCULATING AND MONOCYTE-DERIVED DENDRITIC CELLS IN COLORECTAL CANCER |
| Autori di Ateneo: | |
| Autori: | L. BELLIK; GERLINI, GIANNI; PARENTI, ASTRID; LEDDA, FABRIZIO; PIMPINELLI, NICOLA; NERI, BRUNO; PANTALONE, DESIRE' |
| Data di pubblicazione: | 2006 |
| Rivista: | |
| Volume: | 121(1) |
| Pagina iniziale: | 74 |
| Pagina finale: | 80 |
| Abstract: | ABSTRACT. We investigated the effects of metastasis, surgery and chemotherapy on both circulating dendritic cells (DCs) and monocyte-derived-DCs (MoDCs) in colorectal cancer (CRC) patients. Metastatic or nonmetastatic CRC patients had significantly reduced DC subsets compared to healthy subjects (p<0.001). These cells were significantly higher in metastatic than in nonmetastatic patients. MoDCs were significantly lower in metastatic than healthy and nonmetastatic subjects (p<0.001). Surgically treated patients had nearly one-half circulating DC subsets compared to healthy subjects (p<0.001) while no difference was found between unoperated and healthy subjects. MoDCs obtained from tumor-bearing were significantly higher than in operated subjects. In both cases, MoDCs were significantly lower than in healthy subjects (p<0.001) Circulating DCs and MoDCs were significantly lower in CRC patients, with or without chemotherapy, compared to healthy subjects (p<0.001). Compared to untreated, chemotherapy- treated patients had 30% fewer DC subsets and lower MoDCs. Characterization of circulating DC subsets and MoDCs may elucidate CRC patients’ immune system status. |
| Handle: | http://hdl.handle.net/2158/24584 |
| Appare nelle tipologie: | 1a - Articolo su rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| dendritic cells.pdf | Versione finale referata | DRM non definito | Administrator |
http://hdl.handle.net/2158/24584
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