Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation.
A Diffusion-Ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid / A. R. BILIA; M. BERGONZI; G.A. MORRIS; P. LO NOSTRO; F. F. VINCIERI. - In: JOURNAL OF PHARMACEUTICAL SCIENCES. - ISSN 0022-3549. - ELETTRONICO. - 91:(2002), pp. 2265-2270. [10.1002/jps.10217]
A Diffusion-Ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid
BILIA, ANNA RITA;BERGONZI, MARIA CAMILLA;LO NOSTRO, PIERANDREA;VINCIERI, FRANCO FRANCESCO
2002
Abstract
Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation.
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