CSF114(Glc) is the first synthetic Multiple Sclerosis Antigenic Probe able to identify autoantibodies in a statistically significant number of Multiple Sclerosis patients. The beta-turn conformation of this glucopeptide is fundamental for a correct presentation of the epitope Asn(Glc). To verify the influence of sugar mimics in antibody recognition in Multiple Sclerosis, we synthesized Fmoc-protected Asn derivatives containing alkaloid-type sugar mimics. The corresponding glycomimetics-containing peptide derivatives of the CSF114-type sequence were tested in competitive and solid-phase non-competitive ELISA on Multiple Sclerosis patients’ sera.

Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides / F. NUTI; I. PAOLINI; F. CARDONA; M. CHELLI; F. LOLLI; A. BRANDI; A. GOTI; P. ROVERO; A. M. PAPINI. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 15:(2007), pp. 3965-3973. [10.1016/j.bmc.2007.04.007]

Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides

NUTI, FRANCESCA;I. PAOLINI;CARDONA, FRANCESCA;LOLLI, FRANCESCO;BRANDI, ALBERTO;GOTI, ANDREA;ROVERO, PAOLO;PAPINI, ANNA MARIA
2007

Abstract

CSF114(Glc) is the first synthetic Multiple Sclerosis Antigenic Probe able to identify autoantibodies in a statistically significant number of Multiple Sclerosis patients. The beta-turn conformation of this glucopeptide is fundamental for a correct presentation of the epitope Asn(Glc). To verify the influence of sugar mimics in antibody recognition in Multiple Sclerosis, we synthesized Fmoc-protected Asn derivatives containing alkaloid-type sugar mimics. The corresponding glycomimetics-containing peptide derivatives of the CSF114-type sequence were tested in competitive and solid-phase non-competitive ELISA on Multiple Sclerosis patients’ sera.
2007
15
3965
3973
F. NUTI; I. PAOLINI; F. CARDONA; M. CHELLI; F. LOLLI; A. BRANDI; A. GOTI; P. ROVERO; A. M. PAPINI
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Utilizza questo identificatore per citare o creare un link a questa risorsa: https://hdl.handle.net/2158/308991
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