SPECIFIC AIMS In this study we addressed the hypothesis that thrombospondin- 1 (TSP-1) can exert proangiogenic or anti-angiogenic effects depending on which domain/fragment is functional in a given biological setting. Two fragments of TSP-1 (25 and 140 kDa) generated by the proteolytic cleavage of the intact molecule at a site sensitive to the action of different proteases have been Studied in vivo in the rabbit cornea assay, and the molecular and cellular mechanism have been investigated in vitro on endothelial cells.
The heparin binding 25kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinases and TIMP-2 in endothelial cells / G. TARABOLETTI; L. MORBIDELLI; S. DONNINI; A. PARENTI; H. GRANGER; R. GIAVAZZI; M. ZICHE. - In: THE FASEB JOURNAL. - ISSN 0892-6638. - STAMPA. - 14:(2000), pp. 1674-1676. [10.1096/fj.99-0931fje.]
The heparin binding 25kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinases and TIMP-2 in endothelial cells
PARENTI, ASTRID;
2000
Abstract
SPECIFIC AIMS In this study we addressed the hypothesis that thrombospondin- 1 (TSP-1) can exert proangiogenic or anti-angiogenic effects depending on which domain/fragment is functional in a given biological setting. Two fragments of TSP-1 (25 and 140 kDa) generated by the proteolytic cleavage of the intact molecule at a site sensitive to the action of different proteases have been Studied in vivo in the rabbit cornea assay, and the molecular and cellular mechanism have been investigated in vitro on endothelial cells.File | Dimensione | Formato | |
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