Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Using a combined virtual screening approach, we have identified the pyrazoloquinazoline tricyclic system as a novel scaffold to design new kinase CK2 inhibitors.
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors / S.MORO; F.VARANO; G.COZZA; M.A.PAGANO; G.ZAGOTTO; A.CHILIN; A.GUIOTTO; D.CATARZI; V.COLOTTA; L.A.PINNA; F.MEGGIO.. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - STAMPA. - 3:(2006), pp. 281-284.
Pyrazoloquinazoline tricyclic system as novel scaffold to design new kinase CK2 inhibitors.
VARANO, FLAVIA;CATARZI, DANIELA;COLOTTA, VITTORIA;
2006
Abstract
Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Using a combined virtual screening approach, we have identified the pyrazoloquinazoline tricyclic system as a novel scaffold to design new kinase CK2 inhibitors.
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