Isolated perfused livers were not able to activate the promutagens Trp-P-1 and Trp-P-2 to their genotoxic metabolites. On the contrary, inherently active mutagenic compounds were detected in the bile of living rats to which Trp-P-1 and Trp-P-2 had been administered intravenously. The excretion of active mutagens through the bile may explain the tumorigenic effect that these compounds exert on the liver during chronic feeding experiments.

Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo / P. Dolara; G. Caderni; D. Benetti. - In: NUTRITION AND CANCER. - ISSN 0163-5581. - STAMPA. - 3:(1982), pp. 168-171.

Activation of Trp-P-1 and Trp-P-2 in vitro and in vivo.

DOLARA, PIERO;CADERNI, GIOVANNA;
1982

Abstract

Isolated perfused livers were not able to activate the promutagens Trp-P-1 and Trp-P-2 to their genotoxic metabolites. On the contrary, inherently active mutagenic compounds were detected in the bile of living rats to which Trp-P-1 and Trp-P-2 had been administered intravenously. The excretion of active mutagens through the bile may explain the tumorigenic effect that these compounds exert on the liver during chronic feeding experiments.
3
168
171
P. Dolara; G. Caderni; D. Benetti
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/329001
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