Blood and liver glutathione levels were measured under the effect of an acute exposure to high doses of glutathione-depleting substances. Among direct-acting glutathione-depleting substances, diethyl maleate (0.3, 0.7 and 1.4 ml kg-1) caused a marked reduction of both blood and liver glutathione, whereas methyl iodide (320 mg kg-1) led to a decrease in liver glutathione stores immediately and in blood stores with a longer latency. Indirectly glutathione-depleting substances, like paracetamol (0.5-1.0 g kg-1) and styrene (250 mg kg-1), caused a reduction of liver glutathione, but not a similar reduction of blood glutathione. Blood glutathione is not a good measure of organ glutathione stores when dealing with indirect-acting glutathione-depleting substances.

Blood glutathione as a measure of exposure to toxic compounds / P. Di Simplicio; P. Dolara; M. Lodovici. - In: JOURNAL OF APPLIED TOXICOLOGY. - ISSN 0260-437X. - STAMPA. - 4:(1984), pp. 227-229.

Blood glutathione as a measure of exposure to toxic compounds.

DOLARA, PIERO;LODOVICI, MAURA
1984

Abstract

Blood and liver glutathione levels were measured under the effect of an acute exposure to high doses of glutathione-depleting substances. Among direct-acting glutathione-depleting substances, diethyl maleate (0.3, 0.7 and 1.4 ml kg-1) caused a marked reduction of both blood and liver glutathione, whereas methyl iodide (320 mg kg-1) led to a decrease in liver glutathione stores immediately and in blood stores with a longer latency. Indirectly glutathione-depleting substances, like paracetamol (0.5-1.0 g kg-1) and styrene (250 mg kg-1), caused a reduction of liver glutathione, but not a similar reduction of blood glutathione. Blood glutathione is not a good measure of organ glutathione stores when dealing with indirect-acting glutathione-depleting substances.
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P. Di Simplicio; P. Dolara; M. Lodovici
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2158/329065
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