SPECIFIC AIMS. In this study we addressed the hypothesis that the contribution of bradykinin (BK) to angiogenesis depends on the type of receptor activated in endothelium and the ability to trigger an autocrine loop via the nitric oxide synthase (NOS) pathway. By the use of selective ìagonists and antagonists for the B1 and the B2 receptor, the effect of the kinin was assessed in vivo in the rabbit cornea, and the signaling cascades downstream receptor activation have been investigated on microvascular endothelial cells.
The bradykinin/B1 receptor promotes angiogenesis by upregulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway / A. Parenti; L. Morbidelli; F. Ledda; H. J. Granger; M. Ziche. - In: THE FASEB JOURNAL. - ISSN 0892-6638. - STAMPA. - 15(8):(2001), pp. 1487-1489. [10.1096/fj.00-0503fje]
The bradykinin/B1 receptor promotes angiogenesis by upregulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway
PARENTI, ASTRID;LEDDA, FABRIZIO;
2001
Abstract
SPECIFIC AIMS. In this study we addressed the hypothesis that the contribution of bradykinin (BK) to angiogenesis depends on the type of receptor activated in endothelium and the ability to trigger an autocrine loop via the nitric oxide synthase (NOS) pathway. By the use of selective ìagonists and antagonists for the B1 and the B2 receptor, the effect of the kinin was assessed in vivo in the rabbit cornea, and the signaling cascades downstream receptor activation have been investigated on microvascular endothelial cells.
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